@azzoor has this great video with some advice on how to set up your device for testing accessibility and a ton of tips will get you testing effectively in no time.
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Check for the traversal order of elements in your app. Sometimes, the default top-left to bottom-right order might not be the most logical one. Sometimes, you may consciously want to tweak the order. Some other times, grouping is the answer.

When configuring a largeContentImage or adjustsImageSizeForAccessibilityContentSizeCategory, it is important to use a pdf asset and preserve the vector data so the icons are crisp at any size.

You don't have to offer an alternative layout just for the accessibility category. You can actually compare content size categories. So you could tweak the UI already for anything equal to or larger than .extraExtraLarge, for example.
Content © Daniel Devesa Derksen-Staats on Accessibility up to 11! is licensed under CC BY 4.0. License details