Check for the traversal order of elements in your app. Sometimes, the default top-left to bottom-right order might not be the most logical one. Sometimes, you may consciously want to tweak the order. Some other times, grouping is the answer.

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Make sure you support Dynamic Type up to the largest text size available. Take into account that there are five extra accessibility sizes available from the Accessibility Settings. It can make a huge difference for lots of users.
An alternative layout for large font sizes can be provided with Auto Layout by having three sets of constraints (common, default constraints, and alternative constraints) and activate/deactivate them depending on the content size category.

You can add an observer to listen for changes in the content size category, in case it is more convenient than overriding traitCollectionDidChange(_:).