An alternative layout for large font sizes can be provided with Auto Layout by having three sets of constraints (common, default constraints, and alternative constraints) and activate/deactivate them depending on the content size category.
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When configuring a largeContentImage or adjustsImageSizeForAccessibilityContentSizeCategory, it is important to use a pdf asset and preserve the vector data so the icons are crisp at any size.

Love this feature! Yahoo released the possibility to explore charts with audio, in the finance app, when using screen readers in 2019. You can do now something very similar since iOS 15. https://coolblindtech.com/yahoo-finance-app-makes-charts-accessible-to-blind-and-partially-sighted-users/ You can move your finger in the x-axes, and it will play a sound with a different pitch depending on the data in the y-axes, making it easier to identify trends in the graphs. You need to conform to the AXChart protocol by implementing the accessibilityChartDescriptor property. Documentation: https://developer.apple.com/documentation/accessibility/audio-graphs WWDC21 session: https://developer.apple.com/videos/play/wwdc2021/10122/

Anything representing a heading in the app should have the header trait. It allows for a faster way of exploring a screen and jumping to the part of the app you are interested in. Screens should also start with a header.
Content © Daniel Devesa Derksen-Staats — Accessibility up to 11!