If you are displaying something in two or more columns, you may want to change that to as little as one column when using some of the largest Dynamic Type settings to keep the text readable.

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What is the ideal distance between labels? It depends on styles for both of them and the dynamic type size, right? You wouldn't want to have the same distance for small and large text sizes. We can configure a standard distance between baselines.

Color contrast between text and background is very important for perceivability. As colors come closer to each other, they’re more difficult to distinguish. Notice that colors that work well with big font sizes may not for smaller text.

You don't have to offer an alternative layout just for the accessibility category. You can actually compare content size categories. So you could tweak the UI already for anything equal to or larger than .extraExtraLarge, for example.