When using VoiceOver on a device without a home button it can first be confusing how you can do a few things, including going to Home from an app, or opening the App Switcher, Control Center, or Notifications. Here's a quick guide for you.

VoiceOver's Cheat Sheet number two. There is an iPhone with the Twitter app opened by the TwitterA11y profile screen. Moving your finger up from the bottom till you hear two tones and feel one vibration brings you to Home. Moving your finger up from the bottom till you hear three tones and feel two vibrations brings you to the App Switcher. Moving your finger down from the top till you hear two tones and feel one vibration opens Control Centre. And moving your finger down from the top of the screen till you hear three tones and feel two vibrations brings you to Notifications.