With the attribute accessibilitySpeechPunctuation, you can ask VoiceOver to speak any punctuation marks in your attributed accessibility label, if that is what you want. Good for code snippets?
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You can check if some features, like VoiceOver, are on. Experiences should not diverge too much. It could be used to avoid auto-hiding UI elements. iOS probably checks this to show search fields by default, without having to pull them down. From the documentation: isVoiceOverRunning: https://developer.apple.com/documentation/uikit/uiaccessibility/isvoiceoverrunning
Images should either be decorative or have a proper accessibility label or alt text that describes them. If they're decorative you can make it so they get skipped by assistive tech so it doesn't get in the way of the experience.
Support both orientations, if possible. I know not even iOS itself does it, but it hasn't always been like that. You'll create a more robust UI that will be easier to port to iPadOS. And especially, don't force your users to rotate their devices.
