Consider setting a higher number of lines in your labels for large content size categories. Even to 0 (it means unlimited). That way you ensure the user will have access to the same amount of content regardless of the text size configured.
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When creating AXCustomContent objects for accessibilityCustomContent, you can specify the importance of the data. If it is high, it will always be presented by VoiceOver. You could potentially ask the user if that data is of importance to them.

Love this feature! Yahoo released the possibility to explore charts with audio, in the finance app, when using screen readers in 2019. You can do now something very similar since iOS 15. https://coolblindtech.com/yahoo-finance-app-makes-charts-accessible-to-blind-and-partially-sighted-users/ You can move your finger in the x-axes, and it will play a sound with a different pitch depending on the data in the y-axes, making it easier to identify trends in the graphs. You need to conform to the AXChart protocol by implementing the accessibilityChartDescriptor property. Documentation: https://developer.apple.com/documentation/accessibility/audio-graphs WWDC21 session: https://developer.apple.com/videos/play/wwdc2021/10122/
Check isReduceTransparencyEnabled to lower transparency. A great example is Spotlight. Not only transparency is removed but it keeps the main color of the background, it feels personalized and contextual but reduces noise and improves contrast.