Attributed accessibility labels are a thing! They'll let you specify (for the whole accessibility label or a portion of it) VoiceOver's language, to read punctuation marks, spell it out, correct the pronunciation, or even change the pitch.
@RobRWAPP has a very detailed blog post explaining each one of these attributes: https://mobilea11y.com/blog/attributed-accessibility-labels/
And here's Apple's official documentation for them: https://developer.apple.com/documentation/uikit/speech-attributes-for-attributed-strings
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Sometimes you can create your own accessibility elements from scratch to group elements too. Perhaps because they're not contained in the same superview. You can combine these elements' frames and provide a suitable accessibility label.
A quick way for turning on, or off, VoiceOver is by using Siri. Say something like: "Hey, Siri! Turn on VoiceOver", and you'll find yourself using VoiceOver in no time. You can also do the same with other technologies like Voice Control.
An alternative layout for large font sizes can be provided with Auto Layout by having three sets of constraints (common, default constraints, and alternative constraints) and activate/deactivate them depending on the content size category.
